Fructose facilitates lung metastasis and increases breast cancer risk

Fructose facilitates lung metastasis and increases breast cancer risk

Dietary sugar, especially fructose, significantly increases the risk of breast cancer tumors and metastasis in the lungs, warns an important study. Researchers at the University of Texas MD Anderson Cancer Center have found fructose commonly found in table sugar and high-fructose corn syrup and in many food items to increase breast tumor growth and helps spread it.

In the current study, the researchers have examined the impact of dietary sugar on mammary gland tumor development in many mouse models along with mechanisms involved.

Dr. Lorenzo Cohen, a professor of palliative, rehabilitation, and integrative medicine at MD Anderson, said, “We determined that it was specifically fructose, in table sugar and high-fructose corn syrup, ubiquitous within our food system, which was responsible for facilitating lung metastasis and 12-HETE production in breast tumors”.

The researchers have carried out for different studies on mice and provided them with different diets having different amounts of sucrose and fructose. From the results, the researchers came to that know that to 50 to 58% of mice that were fed with a sucrose-enriched diet developed mammary tumors by the time they were six months old.

But only 30% of mice that were placed on the starch-control diet were found to be having the tumors at the same age. Mice on high sucrose or fructose diets were found to have developed more lung metastases than the ones on the control diet.

Both the sugars produced stimulated 12-LOX and 12-HETE production in breast tumor cells, which increased the tumors size to grow. Dr. Peiying Yang, an assistant professor of palliative, rehabilitation, and integrative medicine at MD Anderson, said that the inflammatory cascade may be an alternative way to study sugar-driven carcinogenesis that encourages to conduct further research. More research is also needed to find whether or not sugar has direct or indirect effect on tumor growth.

RTTNews reported that, they found that sucrose intake in mice comparable with levels of Western diets led to increased tumor growth and metastasis, when compared to a nonsugar starch diet. This was partly because of increased expression of 12-lipoxygenase or 12-LOX and its arachidonate metabolite 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid or 12-HETE.

The researchers determined that fructose derived from the sucrose was responsible for facilitating lung metastasis and 12-HETE production in breast tumors.

Designntrend report said, The researchers led four separate studies involving mice to get the results. The mice were randomly assigned to one of four diet groups, which contained different amounts of sucrose and fructose.

The results showed that 50 to 58 percent of mice that had been fed a sucrose-enriched diet developed mammary tumors by six months old. In comparison, only 30 percent of mice that had been placed on the starch-control diet had detectable tumors by the time they had reached the same age. They also found that mice on high sucrose or fructose diets developed more lung metastases than those on the control diet.

According to the UPI, high levels of sugar typical of Western diets increase the risk for breast cancer tumors and metastasis to the lungs, according to a new study in mice.

Researchers at the University of Texas MD Anderson Cancer Center found fructose -- in table sugar and high-fructose corn syrup, and used in a high percentage of food items -- encouraged breast tumor growth, and helped it spread.